Beilstein J. Org. Chem.2019,15, 2812–2821, doi:10.3762/bjoc.15.274
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Keywords: acetylcholine receptors; bidirectional; photoswitchabledrug; tetrafluoroazobenzene; visible light; Introduction
Starting in 1937, azobenzenes (ABs) have attracted much attention because they undergo a photoreversible chemical transformation of the thermodynamically favored trans configuration
decay is slow at 37 °C, frozen [14] such solutions could be used for many days without any change in pharmacological efficacy.
Our final set of biological experiments with photochrome 2 examined its ability to work as a dynamic, bidirectional photoswitchabledrug for nicotinic acetylcholine receptors
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Graphical Abstract
Figure 1:
Fluoro-AB derivatives and spectra. Structures of 4FAB-diamides [13] cis and trans configurations, and t...